{"id":2195,"date":"2026-09-10T12:22:29","date_gmt":"2026-09-10T09:22:29","guid":{"rendered":"https:\/\/reocell.com\/?p=2195"},"modified":"2026-09-17T12:29:18","modified_gmt":"2026-09-17T09:29:18","slug":"osteoartroz-shho-cze-take-symptomy-vydy-ta-likuvannya","status":"publish","type":"post","link":"https:\/\/reocell.com\/en\/blog\/osteoartroz-shho-cze-take-symptomy-vydy-ta-likuvannya\/","title":{"rendered":"Osteoarthritis: What It Is, Symptoms, Types, and Treatment"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Osteoarthritis is the most common joint disease in the world. According to <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10477960\/\"><span style=\"font-weight: 400;\">Global Burden of Disease<\/span><\/a><span style=\"font-weight: 400;\"> estimates, more than 595 million people were living with osteoarthritis in 2020, accounting for 7.6% of the world&#8217;s population. Early symptoms \u2014 pain with activity, stiffness, and reduced mobility \u2014 should be discussed with a doctor, as early adjustment of physical activity, regular exercise, and weight management can help reduce symptoms and preserve joint function.<\/span><\/p>\n<h2><b>What Is Osteoarthritis and Why Does Cartilage Break Down?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Osteoarthritis is a chronic disease of the entire joint in which the articular cartilage, subchondral bone, and synovial membrane undergo gradual changes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Healthy cartilage covers the ends of the bones within a joint and allows them to glide smoothly during movement. It has no blood vessels of its own and receives nutrients mainly from the synovial fluid. Chondrocytes maintain the structure of cartilage by continuously synthesizing and renewing its extracellular matrix.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In osteoarthritis, this balance is disrupted: the breakdown of matrix components begins to outpace their repair. Gradually, the cartilage loses its normal properties, becomes thinner, and becomes less able to withstand mechanical stress. At the same time, the bone beneath the cartilage changes and becomes denser, while bony outgrowths known as osteophytes may form along the edges of the joint.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The synovial membrane can also be involved. In osteoarthritis, inflammatory changes may develop within it, accompanied by the release of inflammatory mediators that can intensify pain and contribute to further damage to the joint tissues.<\/span><\/p>\n<h2><b>Which Joints Are Most Commonly Affected?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Osteoarthritis can affect a variety of joints. It most commonly develops in the knees and hips, the small joints of the hands, and the spine.<\/span><\/p>\n<h3><b>Knee Osteoarthritis<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Knee osteoarthritis is one of the most common forms of the disease. Damage to the cartilage of the knee joint can cause pain when walking, climbing or descending stairs, as well as a gradual reduction in mobility.<\/span><\/p>\n<h3><b>Hip Osteoarthritis<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Hip osteoarthritis often causes pain in the groin or the front or side of the thigh. Over time, it may become more difficult to walk, climb stairs, bend over, or perform other everyday movements.<\/span><\/p>\n<h3><b>Osteoarthritis of the Small Joints of the Hands and Spine<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">In osteoarthritis of the hands, the finger joints may be affected, sometimes with the formation of Heberden&#8217;s and Bouchard&#8217;s nodes. When the spine is affected, patients may experience pain, stiffness, and reduced mobility.<\/span><\/p>\n<h2><b>Stages of Osteoarthritis: Kellgren\u2013Lawrence Classification<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The radiographic severity of osteoarthritis is commonly assessed using the <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26872913\/\"><span style=\"font-weight: 400;\">Kellgren\u2013Lawrence classification<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<p><b>Stage 0<\/b><span style=\"font-weight: 400;\"> \u2014 no radiographic signs of osteoarthritis.<\/span><\/p>\n<p><b>Stage 1 <\/b><span style=\"font-weight: 400;\">\u2014 doubtful changes, including possible small osteophytes.<\/span><\/p>\n<p><b>Stage 2 <\/b><span style=\"font-weight: 400;\">\u2014 definite osteophytes and possible narrowing of the joint space.<\/span><\/p>\n<p><b>Stage 3 <\/b><span style=\"font-weight: 400;\">\u2014 multiple osteophytes, definite narrowing of the joint space, possible subchondral bone sclerosis, and early deformity of the joint surfaces.<\/span><\/p>\n<p><b>Stage 4<\/b><span style=\"font-weight: 400;\"> \u2014 marked narrowing or near-complete loss of the joint space, pronounced osteophytes, deformity of the joint surfaces, and subchondral bone sclerosis.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The severity of symptoms does not always correspond to the radiographic stage of osteoarthritis. Therefore, treatment decisions also take into account patient-reported symptoms, joint mobility, functional limitations, and the impact of the disease on quality of life.<\/span><\/p>\n<h2><b>Symptoms of Osteoarthritis<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Osteoarthritis usually develops gradually, and the nature of the symptoms depends on the joint affected and the extent of the structural changes. Pain with activity and brief stiffness are often the first symptoms. As the disease progresses, restricted movement, muscle weakness, and joint deformity may develop.<\/span><\/p>\n<h3><b>Early Symptoms<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Pain during movement or physical activity<\/b><span style=\"font-weight: 400;\"> \u2014 at first, it may occur only during prolonged walking, climbing stairs, squatting, or other activities that place stress on the affected joint;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Stiffness after a period of rest<\/b><span style=\"font-weight: 400;\"> \u2014 for example, after waking up or sitting for a long time; it usually lasts no more than 30 minutes;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Crackling or crepitus during movement<\/b><span style=\"font-weight: 400;\"> \u2014 this may result from changes in the joint, but by itself does not indicate osteoarthritis;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>A feeling of discomfort or joint instability during movement<\/b><span style=\"font-weight: 400;\">, especially when the joint is regularly subjected to physical stress.<\/span><\/li>\n<\/ul>\n<h3><b>Later Symptoms<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Pain becomes more frequent<\/b><span style=\"font-weight: 400;\"> and may occur not only with activity but also at rest;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Range of motion decreases<\/b><span style=\"font-weight: 400;\"> \u2014 for example, it may become more difficult to fully bend or straighten a limb, raise an arm, or perform other familiar movements;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Muscle strength around the joint decreases<\/b><span style=\"font-weight: 400;\"> because of pain and reduced physical activity;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Joint deformity develops<\/b><span style=\"font-weight: 400;\">, or the shape of the joint changes;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Everyday function becomes impaired<\/b><span style=\"font-weight: 400;\"> \u2014 it may become more difficult to walk, climb stairs, get dressed, open jars, hold objects, or perform other routine activities, depending on the location of the osteoarthritis.<\/span><\/li>\n<\/ul>\n<h2><b>What Causes Osteoarthritis and Joint Deformity?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Osteoarthritis develops as a result of an imbalance between damage to and repair of the joint tissues. Over time, this leads to changes in the articular cartilage, subchondral bone, synovial membrane, and other structures. Various factors influence the onset and course of the disease, so in most cases it is not possible to identify one specific cause.<\/span><\/p>\n<h3><b>Causes of Osteoarthritis<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Depending on the mechanism of development, osteoarthritis can be classified as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Primary osteoarthritis<\/b><span style=\"font-weight: 400;\"> \u2014 develops without a specific preceding disease or injury and is associated with a combination of age-related, genetic, mechanical, and metabolic factors.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Secondary osteoarthritis<\/b><span style=\"font-weight: 400;\"> \u2014 develops as a result of another condition or joint damage. It may be caused by injuries, fractures involving the joint surface, damage to the menisci and ligaments, congenital or acquired abnormalities of joint structure, and certain inflammatory and metabolic diseases.<\/span><\/li>\n<\/ul>\n<h2><b>Risk Factors for Osteoarthritis<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Risk factors for osteoarthritis include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Age <\/b><span style=\"font-weight: 400;\">\u2014 the risk increases with advancing age;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Excess body weight<\/b><span style=\"font-weight: 400;\"> \u2014 increases mechanical stress on the joints and may also be associated with metabolic changes;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Previous joint injuries<\/b><span style=\"font-weight: 400;\"> \u2014 particularly damage to the menisci, ligaments, and joint surfaces;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Genetic predisposition<\/b><span style=\"font-weight: 400;\"> \u2014 genetic factors can affect joint structure and the properties of cartilage tissue;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Repetitive or excessive joint loading<\/b><span style=\"font-weight: 400;\"> \u2014 including that associated with certain occupations or sports;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Metabolic disorders<\/b><span style=\"font-weight: 400;\"> \u2014 including diabetes and metabolic syndrome.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38212040\/\"><span style=\"font-weight: 400;\">EULAR <\/span><\/a><span style=\"font-weight: 400;\">recommendations, weight management and regular physical activity are important not only for prevention but also for the management of established osteoarthritis.<\/span><\/p>\n<h2><b>How Is Osteoarthritis Diagnosed?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">A diagnosis of osteoarthritis is often based on the patient&#8217;s symptoms and clinical examination findings. The doctor assesses the nature of the pain, morning stiffness, range of motion, deformity, and other clinical signs.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Radiography is performed when it is necessary to clarify the nature of the changes, assess their severity, or rule out other conditions. MRI is used selectively when clinical assessment and radiography are insufficient or when another type of joint injury is suspected. Blood tests do not confirm osteoarthritis but may be needed to rule out other joint diseases.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The diagnostic findings help determine how osteoarthritis should be treated in a particular case.<\/span><\/p>\n<h2><b>How Is Osteoarthritis Treated?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Osteoarthritis requires a comprehensive treatment approach tailored to the affected joint, the severity of symptoms, and the extent of functional limitations.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The cornerstone of treatment is regular <\/span><b>physical exercise, weight management in people who are overweight, and physical therapy<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>Nonsteroidal anti-inflammatory drugs (NSAIDs)<\/b><span style=\"font-weight: 400;\"> are used to reduce pain, while <\/span><b>intra-articular corticosteroids<\/b><span style=\"font-weight: 400;\"> can provide temporary relief, particularly in knee osteoarthritis.<\/span><\/p>\n<p><b>Cell therapy<\/b><span style=\"font-weight: 400;\"> based on mesenchymal stem cells is a promising area that is being actively researched. Clinical studies have reported possible reductions in pain and improvements in joint function; however, the long-term effectiveness and optimal treatment protocols still require further study.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When structural changes are pronounced and function is significantly impaired, and conservative treatments no longer provide sufficient relief, <\/span><b>joint replacement surgery<\/b><span style=\"font-weight: 400;\"> may be considered.<\/span><\/p>\n<h2><b>Can the Progression of Osteoarthritis Be Stopped?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Current treatments for osteoarthritis cannot completely stop or reverse structural changes that have already occurred in the joint. The main goals of treatment are to reduce pain, preserve joint mobility and function, and maintain quality of life.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is also important to manage body weight and maintain an appropriate level of physical activity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Early consultation with a doctor makes it possible to assess the condition of the joint, adjust physical activity, and begin appropriate treatment in a timely manner, including cell therapy. This can help control symptoms and preserve joint function for longer.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If conservative treatment no longer provides sufficient relief and pain and restricted mobility substantially affect everyday life, surgical treatment may be considered.<\/span><\/p>\n<h2><b>Doctor&#8217;s Comment<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cPatients often wait until the pain becomes unbearable and only then seek help. At an early stage, there is the greatest chance of preserving the joint and avoiding surgery,\u201d<\/span><b>&#8211; Dmytro Horban, orthopedic and trauma surgeon, Candidate of Medical Sciences, and Medical Director of ReoCell Clinic.<\/b><\/p>\n<h2><b>How Can Osteoarthritis Be Prevented?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Some risk factors for osteoarthritis, such as age and heredity, cannot be changed. However, other modifiable factors can be addressed to reduce the risk of developing osteoarthritis or slow its progression.<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Maintain a healthy body weight.<\/b><span style=\"font-weight: 400;\"> If you are overweight, gradual weight loss can help reduce stress on the joints.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Stay physically active.<\/b><span style=\"font-weight: 400;\"> Walking, swimming, cycling, and other forms of physical activity help maintain muscle strength and joint function.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Choose comfortable footwear.<\/b><span style=\"font-weight: 400;\"> It should not cause pain or restrict movement.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Manage physical activity appropriately. <\/b><span style=\"font-weight: 400;\">Avoid sudden or excessive stress on the joints and gradually increase the intensity of your workouts.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Recover appropriately after joint injuries.<\/b><span style=\"font-weight: 400;\"> Follow your doctor&#8217;s recommendations for treatment and rehabilitation before returning to your usual level of physical activity.<\/span><\/li>\n<\/ol>\n<h2><b>Sources<\/b><\/h2>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050 (GBD 2021) \u2013<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10477960\/\"><span style=\"font-weight: 400;\"> https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10477960\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis (Bannuru et al., 2019) \u2013<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31278997\/\"> <span style=\"font-weight: 400;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31278997\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update \u2013<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38212040\/\"> <span style=\"font-weight: 400;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38212040\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee \u2013<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31908149\/\"> <span style=\"font-weight: 400;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31908149\/<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis (Kohn et al., 2016) \u2013<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26872913\/\"> <span style=\"font-weight: 400;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26872913\/<\/span><\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Osteoarthritis is the most common joint disease in the world. According to Global Burden of Disease estimates, more than 595 million people were living with osteoarthritis in 2020, accounting for 7.6% of the world&#8217;s population. Early symptoms \u2014 pain with activity, stiffness, and reduced mobility [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":2196,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"post-type":[],"post-whom":[],"service":[],"material":[106],"whom":[],"class_list":["post-2195","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bez-kategoriyi"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Osteoarthritis: What It Is, Symptoms, Types, and Treatment - Reocell<\/title>\n<meta name=\"description\" content=\"Osteoarthritis is the most common joint disease in the world. 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