Clinical Outcomes of Stem Cell Therapy in Traumatology and Orthopedics
The Center for Advanced Cell Technologies ReoCell was represented at the scientific and practical conference ASIR 2026 “Current Challenges in the Treatment of Complications of Traumatic Injuries”, held on March 26–27 in Lviv.
In particular, a scientific presentation was delivered by the Medical Director of ReoCell Clinic, orthopedic surgeon and traumatologist, PhD Dmytro Horban, titled: “OrthobiologicsinModernSurgicalPractice”
RelevanceofCellTherapyinOrthopedics
One of the key messages of the presentation highlighted that degenerative tissue changes are directly associated with chronic inflammation, which progresses with age and leads to a decline in function and quality of life.
Therefore, regenerative medicine is increasingly considered a promising therapeutic approach for degenerative joint disorders.
RoleofMesenchymalStemCells (MSCs)
The presentation emphasized that MSCs represent a key tool in regenerative medicine due to their ability to:
self-renew
secrete growth factors (VEGF, HGF, IGF-1) that promote tissue regeneration
exert immunomodulatory effects
differentiate into bone, cartilage, and adipose tissues
Importantly, the primary therapeutic effect of MSCs is mediated not only through differentiation but predominantly via paracrine signaling and regulation of inflammation.
GlobalContextandEvidenseBase
The presentation also outlined the global development of cell-based therapies:
over 1,500 clinical trials involving MSCs worldwide
approximately 170,000 scientific publications
broad application across multiple fields, including orthopedics, immunology, and inflammatory diseases
These data reflect the growing scientific and clinical interest in regenerative medicine and its integration into modern medical practice.
in some patients, pain was reduced to complete resolution
FunctionalImprovement (WOMAC)
Assessment using the WOMAC scale demonstrated significant functional improvement:
reduction from 80 to 20 points.
Functional Outcomes
Additional findings included:
increase in knee flexion range of motion by 10%
improvement in load-bearing function by 4%
These findings indicate restoration of joint biomechanics.
OutcomesinNonunionCases
Clinical outcomes for long bone nonunions included:
71.4% — complete bone union
28.6% — formation of stable callus
These results demonstrate the potential of MSC therapy in complex clinical scenarios.
SafetyProfile
30% of patients experienced mild synovitis or discomfort
symptoms resolved spontaneously within 1–2 days
no pharmacological intervention was required
ClinicalSignificanse
The obtained results suggest that MSC therapy, as part of a multimodal treatment approach, may:
reduce pain intensity
improve joint function
enhance mobility and quality of life
delay the need for surgical intervention
Participation in ASIR 2026 confirms ReoCell’s active integration into the scientific and medical community of Ukraine.
The presented data demonstrate that cell-based technologies are becoming an important tool in the management of orthopedic conditions, offering new opportunities for disease control and preservation of function.
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